Combined Assessment of WT1 and BAALC Expression Levels Improves Risk Stratification in Myelodysplastic Syndromes

Risk stratification in therapy-related myelodysplastic syndromes

WT1 expression in myelodysplastic syndrome.

Myelodysplastic syndromes are a heterogeneous group of disorders characterized by ineffective hematopoiesis accompanied by morphologic dysplasia [1]. The underlying genetic lesions responsible for the pathogenesis of the disease remain largely elusive. In addition, the diagnosis of low-grade dysplastic process such as refractory anemia (RA) poses a challenge to the clinician as well as to the h...

Myelodysplastic syndromes: recent advancements in risk stratification and unmet therapeutic challenges.

Significant advances have been achieved in understanding and treating myelodysplastic syndromes (MDS) in the past decade. For the first time, three drugs were approved specifically for this disease. Novel sequencing techniques have expanded our understanding of the molecular basis of MDS. Several clinically significant recurrent gene mutations have been identified. The classification and risk s...

PTK2 and PTPN11 expression in myelodysplastic syndromes

OBJECTIVE The aim of this study was to evaluate the expression of protein tyrosine kinase 2 and protein tyrosine phosphatase non-receptor type 11, which respectively encode focal adhesion kinase protein and src homology 2 domain-containing protein-tyrosine phosphatase 2, in hematopoietic cells from patients with myelodysplastic syndromes. METHODS Protein tyrosine kinase 2 and tyrosine phospha...

the role of application of dynamic assessment approach in improvement of iranian efl writing performance at different language proficiency levels

the present study sought to investigate the role of dynamic assessment (da) in improvement of iranian efl writing performance at different language proficiency levels. to this end, after conducting the quick placement test, 60 iranian efl learners were assigned to two groups with different language proficiency levels. in both groups each participant wrote two compositions, one before and one af...